Å·²©ÓéÀÖ

Human health risk assessment

We help drive better health outcomes by delivering human health analyses that turn rigorous science and modern data tools into actionable, policy-ready insights.

Science that informs, data that drives action

We apply clear, evidence-based methods to help evaluate risk, inform decisions, and protect America’s health.

Our multidisciplinary experts bring togeÅ·²©ÓéÀÖr deep scientific knowledge, advanced informatics, and tested technologies to generate insights that are:

  • Transparent and reproducible
  • Decision-ready and adaptable for multiple use cases
  • Built to support cross-agency collaboration and efficiency goals

We turn data into action—supporting health systems that are proactive, accountable, and resilient.

Women looking at a computer screen for systematic literature review

Systematic literature review

Accelerate regulatory timelines with streamlined, evidence-based literature reviews. Since 2014, we’ve led dozens of literature reviews covering thousands of substances—delivering end-to-end support from search strategy to synÅ·²©ÓéÀÖsis. Our approach streamlines evidence-based regulatory decisions.

Toxicology

Make confident, science-based decisions with expert toxicology support. Our toxicologists apply advanced methods—like PBPK and benchmark dose modeling—to evaluate study quality, integrate evidence, and deliver defensible conclusions across a broad range of substances.

New approach methods

We help modernize and scale risk assessments by generating, analyzing, and interpreting mechanistic data, QSAR models, in silico tools, and read-across approaches—advancing Å·²©ÓéÀÖ shift away from animal studies while maintaining scientific rigor.

Epidemiology

Our team interprets and models population-level health data to assess exposure-related risks. We apply meta-analysis and oÅ·²©ÓéÀÖr statistical methods to support hazard identification and quantitative risk conclusions.

Exposure assessment and modeling

Support risk decisions with transparent, policy-ready exposure assessments.

We combine scientific literature, exposure models, and computational methods to quantify and contextualize chemical exposures—and maintain and modernize key regulatory modeling tools to keep your assessments current and credible.

AI solutions

We accelerate reviews and improve reliability through AI-driven tools like Litstream®, which uses artificial intelligence to support literature screening and analysis—bringing innovation and speed to complex assessments.

Our services

Assess

  • Chemical hazard
  • Air quality
  • Food and product safety
  • Library science
  • Data curation and management
  • Statistics

Communicate

  • Data sharing and interoperability
  • Workshop and webinar coordination
  • Science translation and outreach
  • Economic benefit analysis
  • Peer review support
  • Report publishing

Innovate

  • Computational toxicology techniques
  • Machine learning and artificial intelligence
  • Exposure model development
  • Ontologies and knowledge graphs
  • Data visualization
  • App and software development

Our work

Our insights